The station opened on the 1st of January 1859.

In 1933 a military railway line, Longmoor Military Railway was built from Liss Station to the Longmoor Military Camp but was closed in 1969. The platform was adjacent to the mainline.

The railway was used as a film set for many movies including "The Great St Trinian's Train Robbery" which was released in 1966. Extras on the St Trinian's train were from a local convent school. The school used for much of the filming was another local school. In the final railway scene where the girls 'return' the money the British Railways station at Liss can be seen in the background.